| CCRD
CHRONIC RESPIRATORY DISEASE (CRD)
Chronic respiratory disease (CRD) has been reported in chickens and turkeys. CRD is a specific
disease caused by the group of organisms known as pleuropneumonia-like organism (PPLO).
There are more than 100 species of Mycoplasma, 23 of which occurs in birds, to which 4 causes
economic losses. These four species are Mycoplasma gallisepticum (MG), Mycoplasma synoviae (MS)
which affects chicken and turkey, Mycoplasma meleagridis (MM) and Mycoplasma iowae (MI), which
solely affects turkeys.
In boriler M. gallisepticum causes CRD and is being exacerbated by other pathogens like
E.coli,immunosuppresion, dust, ammonia, overcrowding, etc. On the other hand, M. synoviae causes
mild respiratory diseases and occasional synovitis/arthitis. In layers, both species cause egg
production loss.
Mode of transmission is through eggs, but can be also passed from bird to bird through nasal
discharges and droppings. Symptoms includes nasal discharges,coughing, sneezing and swelling of
the face.
Uncomplicated CRD is not a big problem today, however, CRD with co-infection of E.coli causes CCRD
outbreak and high mortalities.
There are control strategies against Avian Mycoplasmosis. Management is a good key to success in
prevention and lowering the cases of CCRD. Ensuring a free-mycoplasma breeder flocks has a big
role in CCRD control. Eradication of MG in primary breeding stock must be in a priority list.
Vaccination in breeders are being incorporated in every breeder flock health program. The use of
antibiotics is also vital in eradication and prevention on both breeder and broilers.
Mycoplasma species are most sensitive to macrolides, ramphenicol group, tetracyclines and
quinolones. |
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CARE/ TREATMENT 
Metaplue is a patented florfenicol developed by KBNP Inc. It inhibits the protein synthesis of bacteria. Metaplue is a patented
product due to its Unique manufacturing process, which contributes to the product stability. It is a broad spectrum antibiotic for
Mycoplasma, gram positive and gram negative bacteria. Unlike chloramphenicol, it is both safe to humans and animals. It does
not impose a risk on development of aplastic anemia in humans.
Metaplue is a fast acting and long lasting florfenicol. It can reach a peak serum level within one hour and has an elimination half life of 18 hours.
Metaplue also uses capric and caprilic acid from as solvents that contributes on better efficacy of Metaplue. Unlike other
solvents, caprylic and capric acid are medium-chained fatty acid which are being absorbed by the digestive tract. These solvents
are non-corrosive and non-toxic because they are derived from coconut extract,thus safe to animal use.
Product Name:METAPLEU PLUS 20% PREMIX
Composition:Florfenicol ……………………………… 200g
Classification:Antibacterials
Packing:1kg, 20kg
Target:Poultry, Swine |
Product Name:METAPLEU PLUS 4% Premix
Composition:Florfenicol ……………………………… 40g
Classification:Antibacterials
Packing:25kg
Target:Swine |
Product Name:METAPLEU 2% PREMIX
Composition:Florfenicol ……………………………… 20g
Classification:Antibacterials
Packing:25kg
Target:Swine |
